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Antimicrobial Agents and Chemotherapy, July 2002, p. 2303-2306, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2303-2306.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

blaCTX-M-2 Is Located in an Unusual Class 1 Integron (In35) Which Includes Orf513

Sonia M. Arduino,1* Paul H. Roy,2 George A. Jacoby,3 Betina E. Orman,1 Silvia A. Pineiro,1 and Daniela Centron1

Facultad de Medicina de la Universidad de Buenos Aires, Paraguay 2155 (1121)Capital Federal, Argentina,1 Département de Biochimie, Faculté des Sciences et de Génie, Université Laval, Sainte-Foy, Québec G1K 7P4, and Centre de Recherche en Infectiologie, Centre de Recherche du CHUL, Sainte-Foy, Québec G1V 4G2, Canada,2 Edith Nourse Rogers Memorial Veterans Hospital, Bedford, and Lahey Clinic, Burlington, Massachusetts3

Received 1 October 2001/ Returned for modification 12 January 2002/ Accepted 7 April 2002

Examination of the blaCTX-M-2 gene in plasmid pMAR-12 by sequencing and PCR analysis revealed that the bla gene and the surrounding DNA, which is closely related (99% homology) to the Kluyvera ascorbata chromosomal DNA that contains the blaKLUA-1 gene, are located in a complex sul1-type integron, termed In35, that includes Orf513. It is possible that blaCTX-M-2 was acquired by plasmid pMAR-12 through an uncharacterized recombinational event in which Orf513 could be involved.

* Corresponding author. Mailing address: Dept. Microbiologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, P-12, (1121) Capital Federal, Argentina. Phone: 5411-4791-9020. Fax: 5411-4508-3705. E-mail: sarduino{at}aol.com.

Antimicrobial Agents and Chemotherapy, July 2002, p. 2303-2306, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2303-2306.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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