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Antimicrobial Agents and Chemotherapy, July 2002, p. 2303-2306, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2303-2306.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

bla_CTX-M-2 Is Located in an Unusual Class 1 Integron (In35) Which Includes Orf513

Facultad de Medicina de la Universidad de Buenos Aires, Paraguay 2155 (1121)Capital Federal, Argentina,¹ Département de Biochimie, Faculté des Sciences et de Génie, Université Laval, Sainte-Foy, Québec G1K 7P4, and Centre de Recherche en Infectiologie, Centre de Recherche du CHUL, Sainte-Foy, Québec G1V 4G2, Canada,² Edith Nourse Rogers Memorial Veterans Hospital, Bedford, and Lahey Clinic, Burlington, Massachusetts³

Received 1 October 2001/ Returned for modification 12 January 2002/ Accepted 7 April 2002

Examination of the bla_CTX-M-2 gene in plasmid pMAR-12 by sequencing and PCR analysis revealed that the bla gene and the surrounding DNA, which is closely related (99% homology) to the Kluyvera ascorbata chromosomal DNA that contains the bla_KLUA-1 gene, are located in a complex sul1-type integron, termed In35, that includes Orf513. It is possible that bla_CTX-M-2 was acquired by plasmid pMAR-12 through an uncharacterized recombinational event in which Orf513 could be involved.

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