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Antimicrobial Agents and Chemotherapy, August 2002, p. 2633-2635, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2633-2635.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Transport of an Antifungal Trypsin Inhibitor Isolated from Corn across the Blood-Brain Barrier

William A. Banks,1,2* Michael L. Niehoff,1,2 Robert L. Brown,3 Zhi-Yuan Chen,4 and Thomas E. Cleveland3

Geriatric Research, Educational, and Clinical Center, Veterans Affairs Medical CenterDivision of Geriatrics, Department of Internal Medicine,1 Saint Louis University School of Medicine, St. Louis, Missouri,2 Agricultural Research Service, New Orleans,3 Department of Plant Pathology and Crop Physiology, Louisiana State University, Baton Rouge, Louisiana4

Received 4 February 2002/ Returned for modification 1 April 2002/ Accepted 22 April 2002

We determined whether an antifungal 14-kDa protein trypsin inhibitor isolated from corn is able to cross the blood-brain barrier. We found that it completely crossed the blood-brain barrier by means of a saturable mechanism at a rate of 0.153 µl/g · min, with about 0.082% of the intravenously injected dose being taken up per gram of brain.

* Corresponding author. Mailing address: 915 N. Grand Blvd., St. Louis, MO 63106. Phone: (314) 289-7084. Fax: (314) 289 6374. E-mail: bankswa{at}slu.edu.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2633-2635, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2633-2635.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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