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Antimicrobial Agents and Chemotherapy, August 2002, p. 2636-2639, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2636-2639.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Salicylate Reduces Susceptibility of Mycobacterium tuberculosis to Multiple Antituberculosis Drugs

Alain Schaller, Zhonghe Sun, Yongping Yang, Akos Somoskovi, and Ying Zhang*

Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205

Received 19 November 2001/ Returned for modification 4 January 2002/ Accepted 1 May 2002

Salicylate induces multiple antibiotic resistance in various bacterial species. Here we investigated the effect of salicylate on the susceptibility of Mycobacterium tuberculosis to a range of antituberculosis (anti-TB) drugs. In the presence of salicylate, the killing effects of isoniazid (INH), rifampin (RMP), ethambutol (EMB), streptomycin (STR), and p-aminosalicylate (PAS) were reduced, as shown with a tetrazolium redox dye viability assay and a bacterial survival assay. Salicylate-induced resistance was more pronounced for PAS, STR, and EMB but was not apparent for INH and RMP when salicylate and the anti-TB agents were incorporated into 7H11 plates. The significance of these findings for TB treatment needs to be further evaluated in vivo.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205. Phone: (410) 614 2975. Fax: (410) 955 0105. E-mail: yzhang{at}jhsph.edu.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2636-2639, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2636-2639.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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