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Antimicrobial Agents and Chemotherapy, August 2002, p. 2687-2691, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2687-2691.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Induction of Apoptosis by a Nonnucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor

A. A. Pilon,1 J. J. Lum,1 J. Sanchez-Dardon,1 B. N. Phenix,1 R. Douglas,1 and A. D. Badley1,2*

Ottawa Health Research Institute, HIV Research Laboratory, Ottawa, Ontario, Canada K1H 8L6,1 Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota 559052

Received 18 December 2001/ Returned for modification 14 March 2002/ Accepted 18 April 2002

Inhibition of human immunodeficiency virus type 1 reverse transcriptase (RT) by both nucleoside and nonnucleoside RT inhibitors profoundly inhibits virus replication. Nucleoside RT inhibitors are known to be toxic, but there is little information regarding the toxicities of nonnucleoside RT inhibitors (NNRTI). We demonstrate that efavirenz (an NNRTI) induces caspase- and mitochondrion-dependent apoptosis of Jurkat T cells and human peripheral blood mononuclear cells. The clinical relevance of these observations is not yet clear.

* Corresponding author. Present address: M.D. FRCPC, Division of Infectious Diseases, Mayo Clinic and Foundation, 200 First St. NW, Rochester, MN 55905. Phone: (507) 255-7761. Fax: (507) 255-7767.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2687-2691, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2687-2691.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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