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Antimicrobial Agents and Chemotherapy, August 2002, p. 2692-2695, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2692-2695.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Two Novel Vaginal Microbicides (Polystyrene Sulfonate and Cellulose Sulfate) Inhibit Gardnerella vaginalis and Anaerobes Commonly Associated with Bacterial Vaginosis

Jose A. Simoes,1,2 Diane M. Citron,3 Alla Aroutcheva,1 Robert A. Anderson, Jr.,1 Calvin J. Chany II,1 Donald P. Waller,4 Sebastian Faro,5 and Lourens J. D. Zaneveld1*

Department of Obstetrics and Gynecology, Rush University,1 Department of Pharmaceutics and Pharmacodynamics, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois,4 Department of Obstetrics and Gynecology, State University of Campinas, São Paulo, Brazil,2 R. M. Alden Research Laboratory, Santa Monica, California,3 Department of Obstetrics and Gynecology, The University of Texas Health Science Center—Houston, and The Woman's Hospital of Texas, Houston, Texas5

Received 6 July 2001/ Returned for modification 24 March 2002/ Accepted 16 May 2002

This is the first report demonstrating the in vitro inhibitory activity of two novel microbicides (cellulose sulfate and polystyrene sulfonate) against bacterial vaginosis (BV)-associated bacteria. Vaginal application of these microbicides not only may reduce the risk of acquisition of human immunodeficiency virus and other sexually transmitted infection-causing organisms but may also decrease the incidence of BV.

* Corresponding author. Mailing address: Rush-Presbyterian-St. Luke's Medical Center, Section of Obstetrics and Gynecology Research, 1653 W. Congress Pkwy., 720 Pav., Chicago, IL 60612. Phone: (312) 942-5442. Fax: (312) 942-2771. E-mail: lzanevel{at}rush.edu.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2692-2695, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2692-2695.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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