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Antimicrobial Agents and Chemotherapy, August 2002, p. 2696-2699, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2696-2699.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Extrusion of Penem Antibiotics by Multicomponent Efflux Systems MexAB-OprM, MexCD-OprJ, and MexXY-OprM of Pseudomonas aeruginosa

Kiyomi Okamoto, Naomasa Gotoh,* and Takeshi Nishino

Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607-8414, Japan

Received 30 October 2001/ Returned for modification 26 February 2002/ Accepted 1 May 2002

The high intrinsic penem resistance of Pseudomonas aeruginosa is due to the interplay among the outer membrane barrier, the active efflux system MexAB-OprM, and AmpC ß-lactamase. We studied the roles of two other efflux systems, MexCD-OprJ and MexXY-OprM, in penem resistance by overexpressing each system in an AmpC- and MexAB-OprM-deficient background and found that MexAB-OprM is the most important among the three efflux systems for extrusion of penems from the cell interior.

* Corresponding author. Mailing address: Department of Microbiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607-8414, Japan. Phone: 81-75-595-4642. Fax: 81-75-583-2230. E-mail: ngotoh{at}mb.kyoto-phu.ac.jp.

Antimicrobial Agents and Chemotherapy, August 2002, p. 2696-2699, Vol. 46, No. 8
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.8.2696-2699.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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