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Antimicrobial Agents and Chemotherapy, September 2002, p. 2821-2828, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.2821-2828.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Antibiotic Resistance Genes and Salmonella Genomic Island 1 in Salmonella enterica Serovar Typhimurium Isolated in Italy

Alessandra Carattoli,1* Emma Filetici,1 Laura Villa,1 Anna Maria Dionisi,1 Antonia Ricci,2 and Ida Luzzi1

Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Rome,1 National Reference Laboratory for Salmonella, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy2

Received 4 September 2001/ Returned for modification 20 October 2001/ Accepted 14 June 2002

Fifty-four epidemiologically unrelated multidrug-resistant Salmonella enterica serovar Typhimurium isolates, collected between 1992 and 2000 in Italy, were analyzed for the presence of integrons. Strains were also tested for Salmonella genomic island 1 (SGI1), carrying antibiotic resistance genes in DT104 strains. A complete SGI1 was found in the majority of the DT104 strains. Two DT104 strains, showing resistance to streptomycin-spectinomycin and sulfonamides, carried a partially deleted SGI1 lacking the flost, tetR, and tetA genes, conferring chloramphenicol-florfenicol and tetracycline resistance, and the integron harboring the pse-1 gene cassette, conferring ampicillin resistance. The presence of SGI1 was also observed in serovar Typhimurium strains belonging to other phage types, suggesting either the potential mobility of this genomic island or changes in the phage-related phenotype of DT104 strains.

* Corresponding author. Mailing address: Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, v.le Regina Elena 299, 00161 Rome, Italy. Phone: 39-06-49903128. Fax: 39-06-49387112. E-mail: alecara{at}iss.it.

Antimicrobial Agents and Chemotherapy, September 2002, p. 2821-2828, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.2821-2828.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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