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Antimicrobial Agents and Chemotherapy, September 2002, p. 2908-2913, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.2908-2913.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

High Incidence of Cefoxitin and Clindamycin Resistance among Anaerobes in Taiwan

Lee-Jene Teng,1,2* Po-Ren Hsueh,2 Jui-Chang Tsai,3,4 Shwu-Jen Liaw,1,2 Shen-Wu Ho,1,2 and Kwen-Tay Luh2

School of Medical Technology,1 Department of Neurosurgery,3 Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine,4 Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan2

Received 20 March 2002/ Returned for modification 24 April 2002/ Accepted 10 June 2002

Susceptibilities to 16 antimicrobial agents were determined by measurement of MICs for 344 isolates of anaerobic bacteria recovered from patients with significant infections. Resistance rates varied among antimicrobial agents and the species tested. The ß-lactams were more active in gram-positive than in gram-negative anaerobes. Resistance to meropenem was low (<1%). For ß-lactam-ß-lactamase inhibitors, piperacillin-tazobactam was most active for all species (resistance, <6%). The rates of resistance to cefoxitin (31 to 65%) and clindamycin (50 to 70%) for non-Bacteroides fragilis species of the B. fragilis group were higher than those for B. fragilis (4% resistant to cefoxitin and 33% resistant to clindamycin). Among members of B. fragilis group, Bacteroides thetaiotaomicron was the most resistant to clindamycin (70%) and cefoxitin (65%). Rates of susceptibility to imipenem and metronidazole for B. fragilis continue to be high compared to those from a previous study 10 years ago. However, resistance to metronidazole was found recently in five strains of B. fragilis. We analyzed the genetic relationships among the metronidazole-resistant B. fragilis strains by pulsed-field gel electrophoresis. The metronidazole-resistant B. fragilis strains showed genotypic heterogeneity, excluding the dissemination of a single clone.

* Corresponding author. Mailing address: School of Medical Technology, College of Medicine, National Taiwan University, No. 1, Chang-Te St., Taipei, Taiwan. Phone: 886-2-23123456, ext. 6918. Fax: 886-2-23711574. E-mail: ljteng{at}ha.mc.ntu.edu.tw.

Antimicrobial Agents and Chemotherapy, September 2002, p. 2908-2913, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.2908-2913.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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