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Antimicrobial Agents and Chemotherapy, September 2002, p. 3031-3034, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3031-3034.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Prospective Survey of ß-Lactamases Produced by Ceftazidime- Resistant Pseudomonas aeruginosa Isolated in a French Hospital in 2000

Christophe De Champs,1* Laurent Poirel,2 Richard Bonnet,1 Danielle Sirot,1 Catherine Chanal,1 Jacques Sirot,1 and Patrice Nordmann2

Service de Bactériologie, Faculté de Médecine, Université d'Auvergne, 63001 Clermont-Ferrand,1 Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France2

Received 24 October 2001/ Returned for modification 7 February 2002/ Accepted 14 May 2002

In 2000, at the Université d'Auvergne teaching hospital in Clermont-Ferrand, France, 44 (6.2%) strains of Pseudomonas aeruginosa were found to be resistant to ceftazidime. After genotyping, 34 strains were selected. Nine had an additional ß-lactamase: OXA-21 (n = 6), PSE-1 (CARB-2) (n = 2), or PER-1 (n = 1). Ceftazidime resistance was related solely to the overproduction of the cephalosporinase in 30 strains. Sequencing of five blaAmpC genes encoding cephalosporinases with different pIs showed 99% identity with the ampC gene of P. aeruginosa PAO1.

* Corresponding author. Mailing address: Faculté de Médecine, Service de Bactériologie, 28, place Henri Dunant, 63001 Clermont-Ferrand Cedex, France. Phone: 33 4 73 17 81 54. Fax: 33 4 73 27 74 94. E-mail: christophe.dechamps{at}u-clermont1.fr.

Antimicrobial Agents and Chemotherapy, September 2002, p. 3031-3034, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3031-3034.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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