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Antimicrobial Agents and Chemotherapy, September 2002, p. 3054-3056, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3054-3056.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Clinical Isolates of Staphylococcus aureus with Ribosomal Mutations Conferring Resistance to Macrolides

Anne-Laure Prunier,1 Brigitte Malbruny,1 Didier Tandé,2 Bertrand Picard,2 and Roland Leclercq1*

Service de Microbiologie, CHU Côte de Nacre, Caen,1 Service de Microbiologie, CHU Morvan, Brest, France2

Received 4 March 2002/ Returned for modification 1 May 2002/ Accepted 3 June 2002

Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the rRNA copies bearing the mutation. One strain displayed an additional mutation in the rplV gene, encoding the L22 ribosomal protein.

* Corresponding author. Mailing address: CHU de Caen, Service de Microbiologie, Avenue Côte de Nacre, 14033 Caen Cedex, France. Phone: (33) 02 31 06 45 72. Fax: (33) 02 31 06 45 73. E-mail: leclercq-r{at}chu-caen.fr.

Antimicrobial Agents and Chemotherapy, September 2002, p. 3054-3056, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3054-3056.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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