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Antimicrobial Agents and Chemotherapy, September 2002, p. 3061-3064, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3061-3064.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Efficacies of Quinupristin-Dalfopristin Combined with Vancomycin In Vitro and in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus in Relation to Cross-Resistance to Macrolides, Lincosamides, and Streptogramin B- Type Antibiotics

Juliette Pavie,1 Agnès Lefort,1 Virginie Zarrouk,1 Françoise Chau,1 Louis Garry,1 Roland Leclercq,2 and Bruno Fantin1*

Institut National de la Santé et de la Recherche Médicale (EMI 9933), Faculté de Médecine Xavier Bichat, Paris ,1 Service de Microbiologie, Hôpital de la Côte de Nacre, Caen, France2

Received 27 December 2001/ Returned for modification 30 March 2002/ Accepted 6 May 2002

A beneficial effect of the combination of quinupristin-dalfopristin and vancomycin was observed against two methicillin-resistant strains of Staphylococcus aureus harboring or not harboring the ermC gene, which codes for constitutive macrolide, lincosamide, and streptogramin B resistance. The beneficial effect was observed in time-kill studies, in which the drugs were used at inhibitory concentrations, and in a rabbit model of endocarditis, in which the combination was highly bactericidal and more active than monotherapies.

* Corresponding author. Mailing address: Service de Médecine Interne, Hôpital Beaujon, 100 Blvd. du général Leclerc, 92118 Clichy Cedex, France. Phone: 01 40 87 58 90. Fax: 01 40 87 10 81. E-mail: bruno.fantin{at}bjn.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, September 2002, p. 3061-3064, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3061-3064.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nguyen, H. M., Graber, C. J. (2010). Limitations of antibiotic options for invasive infections caused by methicillin-resistant Staphylococcus aureus: is combination therapy the answer?. J Antimicrob Chemother 65: 24-36 [Abstract] [Full Text]  


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