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Antimicrobial Agents and Chemotherapy, September 2002, p. 3080-3083, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3080-3083.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Effect of Lamivudine on Transmission of Human T-Cell Lymphotropic Virus Type 1 to Adult Peripheral Blood Mononuclear Cells In Vitro

Emanuela Balestrieri,1 Giancarlo Forte,2 Claudia Matteucci,3 Antonio Mastino,1 and Beatrice Macchi2,4*

Department of Microbiological, Genetic and Molecular Science, University of Messina, Messina,1 Department of Neuroscience,2 Department of Experimental Medicine and Biochemical Science, University of Rome "Tor Vergata",3 IRCCS S. Lucia, Rome, Italy4

Received 25 October 2001/ Returned for modification 17 January 2002/ Accepted 28 May 2002

The effects of lamivudine (3TC) on in vitro infection of peripheral blood mononuclear cells (PBMC) from healthy donors with human T-cell lymphotropic virus type 1 (HTLV-1) were investigated. Direct measures of viral replication (viral DNA, RNA, and protein) all gave similar, very high 50% inhibitory concentrations in comparison with those previously reported for zidovudine. Nevertheless, 3TC inhibited HTLV-1-driven long-term growth of infected PBMC in vitro at concentrations (6.25 µM) which had poor or no direct antiviral effects, suggesting that another mechanism may be playing a role.

* Corresponding author. Mailing address: Department of Neuroscience, University of Rome "Tor Vergata," Via Montpellier 1, 00133 Rome, Italy. Phone: 39/0672596392. Fax: 39/0620427282. E-mail: macchi{at}med.uniroma2.it.

Antimicrobial Agents and Chemotherapy, September 2002, p. 3080-3083, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3080-3083.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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  • Balestrieri, E., Matteucci, C., Ascolani, A., Piperno, A., Romeo, R., Romeo, G., Chiacchio, U., Mastino, A., Macchi, B. (2008). Effect of Phosphonated Carbocyclic 2'-Oxa-3'-Aza-Nucleoside on Human T-Cell Leukemia Virus Type 1 Infection In Vitro. Antimicrob. Agents Chemother. 52: 54-64 [Abstract] [Full Text]  
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