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Antimicrobial Agents and Chemotherapy, September 2002, p. 3094-3095, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3094-3095.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Comparative Activities of the Oxazolidinone AZD2563 and Linezolid against Selected Recent North American Isolates of Streptococcus pneumoniae

Sue E. Baum,1 Sharon A. Crawford,2 M. L. McElmeel,2 Cynthia G. Whitney,3 and James H. Jorgensen2*

Infectious Disease Service of Brooke Army Medical Center,1 University of Texas Health Science Center, San Antonio, Texas,2 Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia3

Received 8 February 2002/ Returned for modification 2 May 2002/ Accepted 5 June 2002

The activity of AZD2563 against 250 highly resistant pneumococci and 267 drug-susceptible isolates was determined. The AZD2563 MICs for 50 and 90% of the strains tested were 1 and 2 µg/ml and 0.5 and 1 µg/ml, respectively, for the two isolate groups. These MICs were within 1 log2 dilution of those of linezolid.

* Corresponding author. Mailing address: Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900. Phone: (210) 567-4088. Fax: (210) 567-2367. E-mail: jorgensen{at}uthscsa.edu.

Antimicrobial Agents and Chemotherapy, September 2002, p. 3094-3095, Vol. 46, No. 9
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.9.3094-3095.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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