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Antimicrobial Agents and Chemotherapy, January 2003, p. 102-105, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.102-105.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Antimicrobial Susceptibilities of Campylobacter Strains Isolated from Finnish Subjects Infected Domestically or from Those Infected Abroad

Hilpi Rautelin,1* Antti Vierikko,1 Marja-Liisa Hänninen,2 and Martti Vaara1

Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, and Helsinki University Central Hospital Laboratory Diagnostics,1 Department of Food and Environmental Hygiene, University of Helsinki, Helsinki, Finland2

Received 21 May 2002/ Returned for modification 5 August 2002/ Accepted 4 October 2002

The in vitro susceptibilities of 678 Campylobacter jejuni and Campylobacter coli strains isolated from stool samples of the same number of Finnish subjects were studied. A total of 523 patients, representing inhabitants from throughout Finland, had not traveled abroad within the 2 weeks prior to becoming ill, whereas 155 persons had presumably acquired their infections abroad. The antimicrobial agents studied were erythromycin, ciprofloxacin, levofloxacin, trovafloxacin, and moxifloxacin. The MICs of these antimicrobial agents were determined by the agar dilution method. The growth of all domestic isolates was inhibited by erythromycin at concentrations of 4 µg/ml, and for these isolates the fluoroquinolone MICs at which 90% of isolates are inhibited (MIC90s) ranged from 0.06 to 0.5 µg/ml. For the foreign isolates, the erythromycin MIC90 was still low (4 µg/ml), but their susceptibilities to fluoroquinolones were clearly reduced (MIC90s, 8 to 64 µg/ml). Of the four different fluoroquinolones studied, ciprofloxacin was the least active (MIC90, 64 µg/ml).

* Corresponding author. Mailing address: Haartman Institute, P.O. Box 21, FIN-00014 University of Helsinki, Helsinki, Finland. Phone: 358 9 1912 6716. Fax: 358 9 1912 6382. E-mail: hilpi.rautelin{at}helsinki.fi.

Antimicrobial Agents and Chemotherapy, January 2003, p. 102-105, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.102-105.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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