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Antimicrobial Agents and Chemotherapy, January 2003, p. 211-215, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.211-215.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Garenoxacin (BMS-284756) and Moxifloxacin in Experimental Meningitis Caused by Vancomycin-Tolerant Pneumococci

Violeta Rodriguez-Cerrato,* Cindy C. McCoig, Jesus Saavedra, Tess Barton, Ian C. Michelow, Robert D. Hardy, Karen Bowlware, Janie Iglehart, Kathy Katz, and George H. McCracken Jr

Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas

Received 22 January 2002/ Returned for modification 23 May 2002/ Accepted 24 September 2002

The emergence of multidrug-resistant strains of Streptococcus pneumoniae drives the development and evaluation of new antipneumococcal agents, especially for the treatment of bacterial meningitis. The aims of the present study were to assess the antibacterial effectiveness of two new quinolones, garenoxacin (BMS; BMS-284756) and moxifloxacin (MOX) in experimental meningitis caused by a vancomycin (VAN)-tolerant S. pneumoniae strain and to compare the results with those obtained by therapy with VAN and ceftriaxone (CRO) in combination. Meningitis was induced in young male New Zealand White rabbits by intracisternal inoculation of a VAN-tolerant pneumococcal strain (strain Tupelo) from a child with meningitis. Sixteen hours after inoculation, therapy was given by intravenous administration of BMS at 20 mg/kg of body weight, followed 5 h later by administration at a dosage of 10 mg/kg (n = 9 animals) or MOX as two doses of 20 mg/kg every 5 h (n = 8 animals). For comparison, we studied the following groups: (i) animals treated with VAN (20 mg/kg every 5 h, three doses) and CRO (125 mg/kg, one dose) (n = 9), (ii) animals infected with a VAN-tolerant strain but not treated (n = 8), (iii) animals infected with a VAN-tolerant pneumococcus isolated from the nasopharynx of a carrier and treated with BMS (n = 8), and (iv) animals infected with a cephalosporin-resistant type 6B S. pneumoniae strain and treated with BMS (n = 6). The MICs of penicillin, CRO, VAN, BMS, and MOX for the Tupelo strain were 2, 1, 0.5, 0.06, and 0.03 µg/ml, respectively. The rates of killing of strain Tupelo (the change in the log10 number of CFU per milliliter per hour) in cerebrospinal fluid at 5 h were -0.70 ± 0.35, -0.61 ± 0.44, and -0.49 ± 0.36 for BMS, MOX, and VAN-CRO, respectively. Therapy with BMS and MOX was as effective as therapy with VAN-CRO against VAN-tolerant pneumococcal meningitis in rabbits.

* Corresponding author. Present address: Department of Clinical Microbiology and Department of Pediatrics, Fundación Jiménez Díaz, Avda. Reyes Católicos 2, Madrid 28040, Spain. Phone: 34-91-550-49-00. Fax: 34-91-549-47-64. E-mail: rodriguez_cerrato{at}yahoo.com.

Antimicrobial Agents and Chemotherapy, January 2003, p. 211-215, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.211-215.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sipahi, O. R., Turhan, T., Pullukcu, H., Calik, S., Tasbakan, M., Sipahi, H., Arda, B., Yamazhan, T., Ulusoy, S. (2008). Moxifloxacin versus ampicillin + gentamicin in the therapy of experimental Listeria monocytogenes meningitis. J Antimicrob Chemother 61: 670-673 [Abstract] [Full Text]  
  • Haase, M. R. (2004). Acute Bacterial Meningitis in Children. Journal of Pharmacy Practice 17: 392-406 [Abstract]  


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