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Antimicrobial Agents and Chemotherapy, January 2003, p. 360-362, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.360-362.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Activities of Moxifloxacin Alone and in Combination with Other Antimicrobial Agents against Multidrug-Resistant Mycobacterium tuberculosis Infection in BALB/c Mice

Lanfranco Fattorini,1 Dejiang Tan,1 Elisabetta Iona,1 Maurizio Mattei,2 Federico Giannoni,1 Lara Brunori,1 Simona Recchia,1 and Graziella Orefici1*

Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità,1 STA, Department of Biology, University of "Tor Vergata," Rome, Italy2

Received 5 August 2002/ Returned for modification 28 August 2002/ Accepted 2 October 2002

The activity of moxifloxacin was enhanced by the addition of ethionamide but not by that of cycloserine, thiacetazone, capreomycin, para-aminosalicylic acid, or linezolid in BALB/c mice infected with a strain of Mycobacterium tuberculosis resistant to isoniazid, rifampin, and six other drugs. These observations are important for the therapy of multidrug-resistant tuberculosis.

* Corresponding author. Mailing address: Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 39 06 49902333. Fax: 39 06 49387112. E-mail: gorefici{at}iss.it.

Antimicrobial Agents and Chemotherapy, January 2003, p. 360-362, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.360-362.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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