This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nakano, T.
Right arrow Articles by Nasu, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nakano, T.
Right arrow Articles by Nasu, M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 2003, p. 363-367, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.363-367.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Clindamycin Modulates Inflammatory-Cytokine Induction in Lipopolysaccharide-Stimulated Mouse Peritoneal Macrophages

Tetsuji Nakano, Kazufumi Hiramatsu, Kenji Kishi, Norio Hirata, Jun-ichi Kadota, and Masaru Nasu*

Second Department of Internal Medicine, Oita Medical University, Hasama, Oita 879-5593, Japan

Received 16 April 2002/ Returned for modification 2 July 2002/ Accepted 2 October 2002

We investigated the mechanism by which clindamycin (CLI) modulates cytokine induction after lipopolysaccharide (LPS) stimulation. Although CLI decreased the intracellular expression levels of tumor necrosis factor alpha and interleukin 1ß (IL-1ß) and increased IL-6 expression in macrophages, cytokine mRNA expression levels were similar in CLI-treated and untreated groups. Our findings suggest that CLI modulates cytokine production in LPS-stimulated macrophages.

* Corresponding author. Mailing address: Second Department of Internal Medicine, Oita Medical University, Hasama, Oita 879-5593, Japan. Phone: 81-97-586-5804. Fax: 81-97-549-4245. E-mail: mnasu{at}oita-med.ac.jp.

Antimicrobial Agents and Chemotherapy, January 2003, p. 363-367, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.363-367.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»