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Antimicrobial Agents and Chemotherapy, January 2003, p. 363-367, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.363-367.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Clindamycin Modulates Inflammatory-Cytokine Induction in Lipopolysaccharide-Stimulated Mouse Peritoneal Macrophages

Tetsuji Nakano, Kazufumi Hiramatsu, Kenji Kishi, Norio Hirata, Jun-ichi Kadota, and Masaru Nasu*

Second Department of Internal Medicine, Oita Medical University, Hasama, Oita 879-5593, Japan

Received 16 April 2002/ Returned for modification 2 July 2002/ Accepted 2 October 2002

We investigated the mechanism by which clindamycin (CLI) modulates cytokine induction after lipopolysaccharide (LPS) stimulation. Although CLI decreased the intracellular expression levels of tumor necrosis factor alpha and interleukin 1ß (IL-1ß) and increased IL-6 expression in macrophages, cytokine mRNA expression levels were similar in CLI-treated and untreated groups. Our findings suggest that CLI modulates cytokine production in LPS-stimulated macrophages.

* Corresponding author. Mailing address: Second Department of Internal Medicine, Oita Medical University, Hasama, Oita 879-5593, Japan. Phone: 81-97-586-5804. Fax: 81-97-549-4245. E-mail: mnasu{at}oita-med.ac.jp.

Antimicrobial Agents and Chemotherapy, January 2003, p. 363-367, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.363-367.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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