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Antimicrobial Agents and Chemotherapy, January 2003, p. 368-370, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.368-370.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Penetration of Dihydroartemisinin into Cerebrospinal Fluid after Administration of Intravenous Artesunate in Severe Falciparum Malaria

Timothy M. E. Davis,1* Tran Quang Binh,2 Kenneth F. Ilett,3,4 Kevin T. Batty,1,5 Hoang Lan Phuöng,2 Gregory M. Chiswell,4 Vu Duong Bich Phuong,2 and Cindy Agus3

Tropical Diseases Research Center, Cho Ray Hospital, Ho Chi Minh City, Vietnam,2 Department of Medicine, University of Western Australia, Fremantle Hospital, Fremantle,1 Department of Pharmacology, University of Western Australia, Crawley,3 Clinical Pharmacology and Toxicology Laboratory, The Western Australian Center for Pathology and Medical Research, Nedlands,4 School of Pharmacy, Curtin University of Technology, Bentley, Australia5

Received 23 January 2002/ Returned for modification 8 September 2002/ Accepted 3 October 2002

Penetration of cerebrospinal fluid (CSF) by artesunate and DHA was assessed in six adults with cerebral or severe malaria. Lumbar punctures were performed on admission and during convalescence, at 15 min (patient 1), 30 min (patient 2), 45 min (patient 3), 60 min (patient 4), 90 min (patient 5), and 120 min (patient 6) after intravenous administration of 120 mg of artesunate. No artesunate was detectable in CSF. In both studies, DHA levels in CSF increased with time while dihydroartemisinin levels in plasma fell. Dihydroartemisinin might accumulate in CSF during frequent artesunate dosing.

* Corresponding author. Mailing address: Department of Medicine, University of Western Australia, Fremantle Hospital, P.O. Box 480, Fremantle 6959, Australia. Phone: 618 9431 3229. Fax: 618 9431 2977. E-mail: tdavis{at}cyllene.uwa.edu.au.

Antimicrobial Agents and Chemotherapy, January 2003, p. 368-370, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.368-370.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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