This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Legat, F. J.
Right arrow Articles by Müller, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Legat, F. J.
Right arrow Articles by Müller, M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 2003, p. 371-374, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.371-374.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Penetration of Fosfomycin into Inflammatory Lesions in Patients with Cellulitis or Diabetic Foot Syndrome

F. J. Legat,1* A. Maier,2 P. Dittrich,3 P. Zenahlik,1 T. Kern,1 S. Nuhsbaumer,2 M. Frossard,4 W. Salmhofer,1 H. Kerl,1 and M. Müller4

Department of Dermatology,1 Department of Surgery, Division of Thoracic and Hyperbaric Surgery, Karl-Franzens-University Graz Medical School, A-8036 Graz,2 Institute of Pharmacology and Toxicology, Karl-Franzens-University Graz, A-8010 Graz,3 Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, A-1090 Vienna, Austria4

Received 25 April 2002/ Returned for modification 26 July 2002/ Accepted 23 October 2002

We investigated the distribution of the broad-spectrum antibiotic fosfomycin in infected soft tissue of patients with uncomplicated cellulitis of the lower extremities or diabetic foot infection using in vivo microdialysis. Our findings suggest that fosfomycin exhibits good and similar penetration into the fluid in the interstitial space in inflamed and noninflamed soft tissue in patients.

* Corresponding author. Mailing address: Department of Dermatology, Karl-Franzens-University Graz Medical School, Auenbruggerplatz 8, A-8036 Graz, Austria. Phone: 43 316 385 2371. Fax: 43 316 385 2466. E-mail: franz.legat{at}uni-graz.at.

Antimicrobial Agents and Chemotherapy, January 2003, p. 371-374, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.371-374.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Schintler, M. V., Traunmuller, F., Metzler, J., Kreuzwirt, G., Spendel, S., Mauric, O., Popovic, M., Scharnagl, E., Joukhadar, C. (2009). High fosfomycin concentrations in bone and peripheral soft tissue in diabetic patients presenting with bacterial foot infection. J Antimicrob Chemother 0: dkp230v1-dkp230 [Abstract] [Full Text]  
  • Skhirtladze, K., Hutschala, D., Fleck, T., Thalhammer, F., Ehrlich, M., Vukovich, T., Muller, M., Tschernko, E. M. (2006). Impaired Target Site Penetration of Vancomycin in Diabetic Patients following Cardiac Surgery.. Antimicrob. Agents Chemother. 50: 1372-1375 [Abstract] [Full Text]  
  • Sauermann, R., Karch, R., Langenberger, H., Kettenbach, J., Mayer-Helm, B., Petsch, M., Wagner, C., Sautner, T., Gattringer, R., Karanikas, G., Joukhadar, C. (2005). Antibiotic Abscess Penetration: Fosfomycin Levels Measured in Pus and Simulated Concentration-Time Profiles. Antimicrob. Agents Chemother. 49: 4448-4454 [Abstract] [Full Text]  
  • Joukhadar, C., Dehghanyar, P., Traunmuller, F., Sauermann, R., Mayer-Helm, B., Georgopoulos, A., Muller, M. (2005). Increase of Microcirculatory Blood Flow Enhances Penetration of Ciprofloxacin into Soft Tissue. Antimicrob. Agents Chemother. 49: 4149-4153 [Abstract] [Full Text]  
  • Legat, F. J., Krause, R., Zenahlik, P., Hoffmann, C., Scholz, S., Salmhofer, W., Tscherpel, J., Tscherpel, T., Kerl, H., Dittrich, P. (2005). Penetration of Piperacillin and Tazobactam into Inflamed Soft Tissue of Patients with Diabetic Foot Infection. Antimicrob. Agents Chemother. 49: 4368-4371 [Abstract] [Full Text]  
  • Lipsky, B. A., Berendt, A. R., Deery, H. G., Embil, J. M., Joseph, W. S., Karchmer, A. W., LeFrock, J. L., Lew, D. P., Mader, J. T., Norden, C., Tan, J. S. (2005). Diagnosis and Treatment of Diabetic Foot Infections. J. Am. Podiatr. Med. Assoc. 95: 183-210 [Full Text]  
  • Muller, M., dela Pena, A., Derendorf, H. (2004). Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue. Antimicrob. Agents Chemother. 48: 1441-1453 [Full Text]  
  • Pfausler, B., Spiss, H., Dittrich, P., Zeitlinger, M., Schmutzhard, E., Joukhadar, C. (2004). Concentrations of fosfomycin in the cerebrospinal fluid of neurointensive care patients with ventriculostomy-associated ventriculitis. J Antimicrob Chemother 53: 848-852 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»