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Antimicrobial Agents and Chemotherapy, January 2003, p. 375-377, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.375-377.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Synergistic Lethal Effect of a Combination of Phage Lytic Enzymes with Different Activities on Penicillin-Sensitive and -Resistant Streptococcus pneumoniae Strains

J. M. Loeffler and V. A. Fischetti*

Laboratory of Bacterial Pathogenesis, The Rockefeller University, New York, New York

Received 17 June 2002/ Returned for modification 20 July 2002/ Accepted 21 September 2002

Pal and Cpl-1, two purified bacteriophage lytic enzymes, were tested for their in vitro activity, alone and in combination, against several serotypes of Streptococcus pneumoniae, including penicillin-resistant strains. The enzymes demonstrated synergism in their ability to cleave the bacterial peptidoglycan and thus may be more efficient for the prevention and elimination of pneumococcal colonization.

* Corresponding author. Mailing address: Laboratory of Bacterial Pathogenesis, The Rockefeller University, Box 172, 1230 York Ave., New York, NY 10021. Phone: (212) 327-8166. Fax: (212) 327-7584. E-mail: vaf{at}mail.rockefeller.edu.

Antimicrobial Agents and Chemotherapy, January 2003, p. 375-377, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.375-377.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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