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Antimicrobial Agents and Chemotherapy, January 2003, p. 405-407, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.405-407.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Activities of HMR 3787 and RU 64399 Compared with Those of Four Other Agents against Haemophilus influenzae and Haemophilus parainfluenzae

Bülent Bozdogan,1 Catherine Clark,1 Andre Bryskier,2 Michael R. Jacobs,3 and Peter C. Appelbaum1*

Hershey Medical Center, Hershey, Pennsylvania,1 Aventis Pharma, Romainville, France,2 Case Western Reserve University, Cleveland, Ohio3

Received 17 June 2002/ Returned for modification 12 September 2002/ Accepted 1 October 2002

Activities of HMR 3787, a new 2-fluoroketolide, and its (des)-fluor derivative, RU 64399, were tested against 111 Haemophilus influenzae and 26 H. parainfluenzae strains and compared with those of telithromycin, erythromycin, azithromycin, and clarithromycin. HMR 3787 and RU 64399 MICs were comparable with those of azithromycin but were less affected by incubation in CO2. Time-kill studies of 12 strains showed that HMR 3787, RU 64399, and telithromycin were bactericidal against all strains after 24 h at two times the MIC.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, 500 University Dr., Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, January 2003, p. 405-407, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.405-407.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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