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Antimicrobial Agents and Chemotherapy, January 2003, p. 418-420, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.418-420.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Bactericidal Activities of Linezolid in Combination with Vancomycin, Gentamicin, Ciprofloxacin, Fusidic Acid, and Rifampin against Staphylococcus aureus

Patrick Grohs,1 Marie-Dominique Kitzis,2 and Laurent Gutmann1,3*

Hôpital Européen Georges Pompidou,1 Hôpital Saint Joseph,2 Laboratoire de Recherche Moléculaire sur les Antibiotiques, Université Paris VI, Paris, France3

Received 19 April 2002/ Returned for modification 24 July 2002/ Accepted 23 October 2002

The in vitro activities of linezolid were determined alone and in combination with vancomycin, ciprofloxacin, gentamicin, fusidic acid, or rifampin against five methicillin-susceptible Staphylococcus aureus (MSSA) and five methicillin-resistant S. aureus (MRSA) strains. Similar responses were obtained against MSSA and MRSA. When combined with fusidic acid, gentamicin, or rifampin, linezolid prevented selection of resistant mutants but showed no synergy. When linezolid was combined with vancomycin and ciprofloxacin, a slight antagonism was observed. While the combination with linezolid may reduce the emergence of mutants resistant to the associated drugs, the absence of synergy, especially in the case of vancomycin and ciprofloxacin, does not argue in favor of such combinations.

* Corresponding author. Mailing address: Laboratoire de Microbiologie, Hôpital Européen Georges Pompidou, 20, rue Leblanc, 75908 Paris Cedex 15, France. Phone: 33 1 56 09 39 51. Fax: 33 1 56 09 24 46. E-mail: laurent.gutmann{at}hop.egp.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, January 2003, p. 418-420, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.418-420.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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