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Antimicrobial Agents and Chemotherapy, January 2003, p. 421-426, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.421-425.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Class 1 Integron-Borne Gene Cassettes in Multidrug-Resistant Yersinia enterocolitica Strains of Different Phenotypic and Genetic Types

S. M. Soto, M. J. Lobato, and M. C. Mendoza*

Departamento de Biología Funcional, Area Microbiología, Facultad de Medicina, Universidad de Oviedo, 33006-Oviedo, Spain

Received 10 December 2001/ Returned for modification 19 July 2002/ Accepted 17 October 2002

Seventy nine strains of Yersinia enterocolitica resistant to one or more antimicrobials were analyzed for integrons. Only class 1 sul1 integrons containing aadA1a (28 strains), aadA1a-dfr1-sat1 (2 strains), and dfr1-aadA1a (1 strain) gene cassettes were found. The first two types were found in clinical isolates belonging to serotype O:3, biotypes 2 to 4, and eight combined ribotypes, and the third was found in the reference strain, CECT4054 (O:8). All screened resistance markers were found in strains with and without integrons (except for chloramphenicol resistance, encoded by catA1 gene, which was only present in strains with integrons), but in different resistance profiles (R profiles). A profile (ampicillin, streptomycin, sulfadiazine, and trimethoprim resistance, encoded by the tem1, aadA1a, sul1, and dfr1 genes, respectively) was found in strains, with and without integrons. Integrons and some of the resistance genes are located on plasmids with sizes ranging between 65 and 140 kb. This is the first report of class 1 integrons in Y. enterocolitica.

* Corresponding author. Mailing address: Area de Microbiología. Facultad de Medicina, C/Julián Clavería 6., 33006-Oviedo, Spain. Fax: 34-985103148. E-mail: cmendoza{at}correo.uniovi.es.

Antimicrobial Agents and Chemotherapy, January 2003, p. 421-426, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.421-425.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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