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Antimicrobial Agents and Chemotherapy, January 2003, p. 436-439, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.436-439.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Quinolone-Resistant Neisseria gonorrhoeae in Hong Kong

Kai Man Kam,* Shirley Sin Yee Kam, Danny Tze Leung Cheung, Viola Wai Na Tung, Wai Fun Au, and May May Cheung

Sexually Transmitted Diseases Laboratory, Public Health Laboratory Centre, Pathology Service, Department of Health, Kowloon, Hong Kong, China

Received 12 April 2002/ Returned for modification 20 June 2002/ Accepted 17 September 2002

In Hong Kong, ParC changes among high-level quinolone-resistant Neisseria gonorrhoeae (QRNG) isolates at Ser-87->Arg were associated with a higher level of resistance than a Ser-87->Ile alteration. Two previously undescribed mutations in clinical isolates occurring in gyrA, conferring Ala-92->Pro and Asp-95->Tyr changes, were detected. Nine different outer membrane lipoprotein (Lip) repeat classes—11 to 19 repeats—were identified, with repeat lengths of 16 and 17 the most common, indicating considerable strain diversity.

* Corresponding author. Mailing address: Rm. 731, 7/F, Public Health Laboratory Centre, 382 Nam Cheong St., Shek Kip Mei, Kowloon, Hong Kong. Fax: (852) 2776-1446. E-mail: kmkam{at}dh.gov.hk.

Antimicrobial Agents and Chemotherapy, January 2003, p. 436-439, Vol. 47, No. 1
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.1.436-439.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zhou, W., Du, W., Cao, H., Zhao, J., Yang, S., Li, W., Shen, Y., Zhang, S., Du, W., Zhang, X. (2004). Detection of gyrA and parC Mutations Associated with Ciprofloxacin Resistance in Neisseria gonorrhoeae by Use of Oligonucleotide Biochip Technology. J. Clin. Microbiol. 42: 5819-5824 [Abstract] [Full Text]  


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