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Antimicrobial Agents and Chemotherapy, October 2003, p. 3085-3088, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3085-3088.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Three Licensed Antifungal Agents against Spanish Clinical Isolates of Aspergillus spp.

Alicia Gomez-Lopez,1 Guillermo Garcia-Effron,2 Emilia Mellado,1 Araceli Monzon,1 Juan L. Rodriguez-Tudela,1 and Manuel Cuenca-Estrella1*

Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain,1 Universidad Nacional del Litoral, Santa Fe, Argentina2

Received 30 April 2003/ Returned for modification 18 June 2003/ Accepted 2 July 2003

The aim of the present study was to identify retrospectively trends in the species distributions and the susceptibility patterns of Aspergillus species causing fungal infections in Spanish medical centers from 2000 to 2002. The susceptibilities of 338 isolates to amphotericin B, itraconazole, and voriconazole were tested. Aspergillus fumigatus was the most common species (54.7%), followed by Aspergillus terreus (14.8%) and Aspergillus flavus (13.9%). Non-A. fumigatus species were encountered in 45.3% of the samples studied. The majority of Aspergillus isolates were obtained from respiratory tract specimens, followed by ear and skin samples. The geometric mean (GM) MIC of amphotericin B was 0.56 µg/ml, and the amphotericin B MIC was >2 µg/ml for 16 isolates (4.7%). Nine of them were A. terreus. The GM MIC of itraconazole was 0.37, and the itraconazole MIC was >4 µg/ml for 12 (3.5%) isolates. The voriconazole MICs were also high for 8 of the 12 strains for which itraconazole MICs were high (voriconazole MIC range, 2 to 8 µg/ml).

* Corresponding author. Mailing address: Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo Km 2, 28220 Majadahonda (Madrid), Spain. Phone: 34-91-5097961. Fax: 34-91-5097966. E-mail: mcuenca-estrella{at}isciii.es.

Antimicrobial Agents and Chemotherapy, October 2003, p. 3085-3088, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3085-3088.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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