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Antimicrobial Agents and Chemotherapy, October 2003, p. 3318-3320, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3318-3320.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Recombination Proficiency Influences Frequency and Locus of Mutational Resistance to Linezolid in Enterococcus faecalis

Michael Lobritz,1 Rebecca Hutton-Thomas,2 Steve Marshall,2 and Louis B. Rice2*

Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine,1 Division of Infectious Diseases, Research and Medical Services, Department of Veterans Affairs Medical Center, Cleveland, Ohio2

Received 13 May 2003/ Returned for modification 9 June 2003/ Accepted 2 July 2003

In vitro linezolid resistance was selected at a higher frequency in Enterococcus faecalis JH2-2 than in recombination-deficient E. faecalis UV202. Resistance in JH2-2 was related to accumulated G2576T mutations in 23S rRNA genes, with the least resistance conferred by mutations in two of four copies. UV202 resistance was associated with a G2505A mutation present in a single copy in mutants with different MICs.

* Corresponding author. Mailing address: Medical Service 111(W), VA Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800, ext. 4801. Fax: (216) 231-3289. E-mail: louis.rice{at}med.va.gov.

Antimicrobial Agents and Chemotherapy, October 2003, p. 3318-3320, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3318-3320.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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