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Antimicrobial Agents and Chemotherapy, October 2003, p. 3326-3331, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3326-3331.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Erythromycin Esterase Gene ere(A) Is Located in a Functional Gene Cassette in an Unusual Class 2 Integron

Latefa Biskri and Didier Mazel*

Unité de Programmation Moléculaire et Toxicologie Génétique, CNRS URA 1444, Département de Microbiologie Fondamentale et Médicale, Institut Pasteur, 75724, Paris, France

Received 2 December 2002/ Returned for modification 10 March 2003/ Accepted 12 July 2003

The gene ere(A) of the plasmid pIP1100 is larger than originally reported and is organized as an integron gene cassette. The ere(A) gene cassette carries its own promoter and is propagated by a class 2 integron with an insertion sequence element, IS1, inserted upstream of the intI2 gene. The mobility of the ere(A) cassette has been demonstrated.

* Corresponding author. Mailing address: UPMTG, Département de Microbiologie Fondamentale et Médicale, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris, France. Phone: 33 1 40 61 32 84. Fax: 33 1 45 68 88 34. E-mail: mazel{at}pasteur.fr.

Antimicrobial Agents and Chemotherapy, October 2003, p. 3326-3331, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3326-3331.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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