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Antimicrobial Agents and Chemotherapy, October 2003, p. 3336-3338, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3336-3338.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

PCR and Restriction Endonuclease Assay for Detection of a Novel Mutation Associated with Sulfonamide Resistance in Neisseria meningitidis

Désirée E. Bennett1 and Mary T. Cafferkey1,2*

Epidemiology and Molecular Biology Unit, The Children's University Hospital,1 Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland2

Received 29 January 2003/ Returned for modification 16 April 2003/ Accepted 16 July 2003

We identified a previously undocumented mutation in the dihydropteroate synthase (folP) gene associated with Neisseria meningitidis sulfonamide resistance. A PCR-based assay to detect this mutation, which is 100% predictive of sulfonamide resistance, was developed.

* Corresponding author. Mailing address: Epidemiology and Molecular Biology Unit, The Children's University Hospital, Temple St., Dublin 1, Ireland. Phone: 353-1-878-4858. Fax: 353-1-878-4856. E-mail: M.Cafferkey{at}tsch.ie.

Antimicrobial Agents and Chemotherapy, October 2003, p. 3336-3338, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3336-3338.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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