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Antimicrobial Agents and Chemotherapy, October 2003, p. 3352-3356, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3352-3356.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Postantibiotic, Postantibiotic Sub-MIC, and Subinhibitory Effects of PGE-9509924, Ciprofloxacin, and Levofloxacin

Inga Odenholt,* Elisabeth Löwdin, and Otto Cars

Antibiotic Research Unit, Department of Infectious Diseases and Clinical Microbiology, University Hospital, Uppsala, Sweden

Received 2 December 2002/ Returned for modification 17 May 2003/ Accepted 13 July 2003

Postantibiotic effects (PAEs), postantibiotic sub-MIC effects, and sub-MIC effects of the new nonfluoroquinolone PGE-9509924, ciprofloxacin, and levofloxacin against gram-positive and gram-negative strains were investigated. In comparison to ciprofloxacin and levofloxacin, PGE-9509924 exerted very similar PAEs against all strains except for both strains of Streptococcus pneumoniae, where longer PAEs were found for PGE-9509924. All three investigated quinolones showed no minimal PAEs against Pseudomonas aeruginosa.

* Corresponding author. Mailing address: Department of Infectious Diseases, University Hospital MAS, 20502 Malmö, Sweden. Phone: (46)-40-331806. Fax: (46)-40-336279. E-mail: inga.odenholt{at}inf.mas.lu.se.

Antimicrobial Agents and Chemotherapy, October 2003, p. 3352-3356, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3352-3356.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Stubbings, W. J., Bostock, J. M., Ingham, E., Chopra, I. (2004). Assessment of a microplate method for determining the post-antibiotic effect in Staphylococcus aureus and Escherichia coli. J Antimicrob Chemother 54: 139-143 [Abstract] [Full Text]  


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