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Antimicrobial Agents and Chemotherapy, October 2003, p. 3361-3364, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3361-3364.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Interaction of Flucytosine with Conventional and New Antifungals against Cryptococcus neoformans Clinical Isolates

Patrick Schwarz, Françoise Dromer, Olivier Lortholary, and Eric Dannaoui*

Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, Institut Pasteur, 75724 Paris Cedex 15, France

Received 10 April 2003/ Returned for modification 17 June 2003/ Accepted 30 June 2003

Combinations of flucytosine with conventional and new antifungals were evaluated in vitro against 30 clinical isolates of Cryptococcus neoformans. Synergy determined by checkerboard analysis was observed with combinations of fluconazole, itraconazole, voriconazole, amphotericin B, and caspofungin with flucytosine against 77, 60, 80, 77, and 67% of the isolates, respectively. Antagonism was never observed. Killing curves showed indifferent interactions between triazoles and flucytosine and synergy between amphotericin B and flucytosine.

* Corresponding author. Mailing address: Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 33 1 40 61 32 50. Fax: 33 1 45 68 84 20. E-mail: dannaoui{at}pasteur.fr.

Antimicrobial Agents and Chemotherapy, October 2003, p. 3361-3364, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3361-3364.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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