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Antimicrobial Agents and Chemotherapy, October 2003, p. 3365-3367, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3365-3367.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Teicoplanin-Containing Cement Spacers for Treatment of Experimental Staphylococcus aureus Joint Prosthesis Infection

Farid Ismael,1 Rémy Bléton,1 Azzam Saleh-Mghir,2 Sophie Dautrey,3 Laurent Massias,3 and Anne-Claude Crémieux2*

Department of Orthopedic Surgery,1 Institut National de la Santé et de la Recherche Médicale,2 Department of Toxicology, Bichat-Claude Bernard Hospital, Paris, France3

Received 30 May 2002/ Returned for modification 9 February 2003/ Accepted 15 July 2003

Using a rabbit model of methicillin-resistant Staphylococcus aureus knee-prosthesis infection, we studied the efficacy of teicoplanin cement alone or in combination with systemic intramuscular (i.m.) injections of teicoplanin. Seven days after infection, surgical debridement and removal of the infected prostheses were performed, and five rabbits were randomly assigned to one of five different treatment groups: untreated controls, prosthesis replacement by drug-free cement spacer, prosthesis replacement by teicoplanin-loaded cement spacer (1.2 g of teicoplanin/40 g of cement), i.m. injections of teicoplanin (20 mg/kg of body weight, twice a day for 7 days), or systemic antibiotic treatment combined with teicoplanin-loaded spacers. The most effective regimen combined systemic teicoplanin and antibiotic spacers.

* Corresponding author. Mailing address: Hôpital Bichat-Claude Bernard, 75877 Paris Cedex 18, France. Phone: 33 (1) 40 56 79 23. Fax: 33 (1) 40 56 43 33. E-mail: anne-claude.cremieux{at}sante.gouv.fr.

Antimicrobial Agents and Chemotherapy, October 2003, p. 3365-3367, Vol. 47, No. 10
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.10.3365-3367.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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