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Antimicrobial Agents and Chemotherapy, November 2003, p. 3598-3601, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3598-3601.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Active Internalization of the Penicillium chrysogenum Antifungal Protein PAF in Sensitive Aspergilli

Christoph Oberparleiter,1 Lydia Kaiserer,1 Hubertus Haas,1 Peter Ladurner,2 Manfred Andratsch,1,{dagger} and Florentine Marx1*

Department of Molecular Biology,1 Institute of Zoology and Limnology, University of Innsbruck, Innsbruck, Austria2

Received 20 May 2003/ Returned for modification 2 July 2003/ Accepted 21 August 2003

The Penicillium chrysogenum antifungal protein PAF inhibits the growth of various filamentous fungi. In this study, PAF was found to localize to the cytoplasm of sensitive aspergilli by indirect immunofluorescence staining. The internalization process required active metabolism and ATP and was prevented by latrunculin B, suggesting an endocytotic mechanism.

* Corresponding author. Mailing address: Department of Molecular Biology, Leopold Franzens University, Peter-Mayr Strasse 4b/III, A-6020 Innsbruck, Austria. Phone: 43-512-5073607. Fax: 43-512-5072866. E-mail: florentine.marx{at}uibk.ac.at.

{dagger} Present address: Institute of Physiology and Balneology, University of Innsbruck, A-6020 Innsbruck, Austria.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3598-3601, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3598-3601.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Leiter, E., Szappanos, H., Oberparleiter, C., Kaiserer, L., Csernoch, L., Pusztahelyi, T., Emri, T., Pocsi, I., Salvenmoser, W., Marx, F. (2005). Antifungal Protein PAF Severely Affects the Integrity of the Plasma Membrane of Aspergillus nidulans and Induces an Apoptosis-Like Phenotype. Antimicrob. Agents Chemother. 49: 2445-2453 [Abstract] [Full Text]  


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