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Antimicrobial Agents and Chemotherapy, November 2003, p. 3610-3612, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3610-3612.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Effect of Parenteral Antibiotic Administration on Establishment of Intestinal Colonization in Mice by Klebsiella pneumoniae Strains Producing Extended-Spectrum ß-Lactamases

Claudia K. Hoyen,1 Nicole J. Pultz,2 David L. Paterson,3 David C. Aron,4 and Curtis J. Donskey2*

Pediatric Infectious Diseases, Rainbow Babies and Childrens Hospital,1 Infectious Diseases Section,2 Center for Quality Improvement Research, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106,4 Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 152613

Received 7 October 2002/ Returned for modification 21 February 2003/ Accepted 18 July 2003

A mouse model was used to test the hypothesis that antibiotics with activity against anaerobes promote overgrowth of extended-spectrum ß-lactamase-producing Klebsiella pneumoniae strains in stool. Subcutaneous clindamycin consistently promoted establishment of high-density colonization, whereas piperacillin-tazobactam, ceftriaxone, and ceftazidime promoted colonization only when a large inoculum and/or more resistant strain was administered.

* Corresponding author. Mailing address: Infectious Diseases Section (111 W), Louis Stokes Cleveland VA Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800. Fax: (216) 229-8509. E-mail: curtisd123{at}yahoo.com.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3610-3612, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3610-3612.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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