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Antimicrobial Agents and Chemotherapy, November 2003, p. 3610-3612, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3610-3612.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Effect of Parenteral Antibiotic Administration on Establishment of Intestinal Colonization in Mice by Klebsiella pneumoniae Strains Producing Extended-Spectrum ß-Lactamases

Pediatric Infectious Diseases, Rainbow Babies and Childrens Hospital,¹ Infectious Diseases Section,² Center for Quality Improvement Research, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106,⁴ Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261³

Received 7 October 2002/ Returned for modification 21 February 2003/ Accepted 18 July 2003

A mouse model was used to test the hypothesis that antibiotics with activity against anaerobes promote overgrowth of extended-spectrum ß-lactamase-producing Klebsiella pneumoniae strains in stool. Subcutaneous clindamycin consistently promoted establishment of high-density colonization, whereas piperacillin-tazobactam, ceftriaxone, and ceftazidime promoted colonization only when a large inoculum and/or more resistant strain was administered.

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