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Antimicrobial Agents and Chemotherapy, November 2003, p. 3613-3615, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3613-3615.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Recombinant Lysostaphin against Staphylococcus aureus Isolates from Anterior Nares and Blood

Christof von Eiff,1* John F. Kokai-Kun,2 Karsten Becker,1 and Georg Peters1

Institute of Medical Microbiology, University of Münster Hospital and Clinics, 48149 Münster, Germany,1 Department of Microbiology, Biosynexus Incorporated, Gaithersburg, Maryland2

Received 7 May 2003/ Returned for modification 9 June 2003/ Accepted 25 July 2003

The in vitro activity of recombinant lysostaphin was tested against a collection of well-characterized clinical Staphylococcus aureus isolates by disk diffusion (429 isolates) and minimum bactericidal concentration (10 isolates) assays. Minimum bactericidal concentrations of 0.16 µg/ml and zones of inhibition ranging between 15 and 21 mm in diameter demonstrate that lysostaphin was highly active against all isolates tested.

* Corresponding author. Mailing address: Institute of Medical Microbiology, University of Münster Hospital and Clinics, Domagkstraße 10, 48149 Münster, Germany. Phone: 49-251-835-5360. Fax: 49-251-835-5350. E-mail: eiffc{at}uni-muenster.de.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3613-3615, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3613-3615.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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