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Antimicrobial Agents and Chemotherapy, November 2003, p. 3623-3626, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3623-3626.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

R57K Polymorphism in the Human Immunodeficiency Virus Type 1 Protease as Predictor of Early Virological Failure in a Cohort of Antiretroviral-Naive Patients Treated Mostly with a Nelfinavir-Containing Regimen

Laboratoire de Virologie, Hôpital Pellegrin, and,¹ INSERM U 593, Université Victor Segalen Bordeaux 2, Bordeaux,² Laboratoire de Virologie, Hôpital Bichat Claude Bernard, Paris,³ Service des Maladies Infectieuses, Hôpital Raymond Poincaré, Garches,⁴ Laboratoire de Virologie,⁵ Service des Maladies Infectieuses et Tropicales, Hôtel Dieu de Nantes, Nantes,⁷ INSERM U 379, Marseille, France⁶

Received 27 May 2003/ Returned for modification 21 July 2003/ Accepted 26 August 2003

In 243 antiretroviral-naive human immunodeficiency-infected patients starting a first-line-protease inhibitor (mainly nelfinavir)-containing therapy, the presence of the polymorphism R57K in the protease at the inception of therapy was independently associated with a higher rate of virological failure.

² Members of the APROCO/COPILOTE study group are listed in the Acknowledgments.

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