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Antimicrobial Agents and Chemotherapy, November 2003, p. 3627-3629, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3627-3629.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Flow Cytometry Antifungal Susceptibility Testing of Aspergillus fumigatus and Comparison of Mode of Action of Voriconazole vis-à-vis Amphotericin B and Itraconazole

Rama Ramani,1 Madhurama Gangwar,1,{dagger} and Vishnu Chaturvedi1,2*

Mycology Laboratory, Wadsworth Center, New York State Department of Health,1 Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Albany, New York2

Received 31 March 2003/ Returned for modification 15 May 2003/ Accepted 22 July 2003

Aspergillus fumigatus isolates were tested with three antifungals by flow cytometry (FC) and fluorescence-activated cell sorting. FC results after 4 h correlated well with MICs obtained by the NCCLS M38-A method; voriconazole exhibited fungicidal activity, albeit to a lesser extent than amphotericin B, but to a greater extent than itraconazole.

* Corresponding author. Mailing address: Mycology Laboratory, Wadsworth Center, New York State Department of Health, 120 New Scotland Ave., Albany, NY 12208-2002. Phone: (518) 474-4177. Fax: (518) 486-7811. E-mail: vishnu{at}wadsworth.org.

{dagger} Present address: Department of Animal Nutrition, Punjab Agricultural University, Ludhiana, India.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3627-3629, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3627-3629.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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