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Antimicrobial Agents and Chemotherapy, November 2003, p. 3630-3633, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3630-3633.2003

Doxycycline Is Anti-Inflammatory and Inhibits Staphylococcal Exotoxin-Induced Cytokines and Chemokines

Teresa Krakauer* and Marilyn Buckley

Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011

Received 21 March 2003/ Returned for modification 28 May 2003/ Accepted 21 July 2003

Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells. These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.

* Corresponding author. Mailing address: Department of Immunology and Molecular Biology, 1425 Porter St., USAMRIID, Fort Detrick, MD 21702-5011. Phone: (301) 619-4733. Fax: (301) 619-2348. E-mail: Teresa.Krakauer{at}det.amedd.army.mil.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3630-3633, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3630-3633.2003




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