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Antimicrobial Agents and Chemotherapy, November 2003, p. 3657-3659, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3657-3659.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Antifungal Combinations against Candida albicans Biofilms In Vitro

Stefano P. Bachmann,1,{dagger} Gordon Ramage,2 Kacy VandeWalle,1 Thomas F. Patterson,1 Brian L. Wickes,2 and José L. López-Ribot1,2*

Division of Infectious Diseases, Department of Medicine,1 Department of Microbiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas2

Received 10 February 2003/ Returned for modification 13 March 2003/ Accepted 11 August 2003

Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

* Corresponding author. Mailing address: Department of Medicine/Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, South Texas Centers for Biology in Medicine, Texas Research Park, 15355 Lambda Dr., San Antonio, TX 78245. Phone: (210) 562-5017. Fax: (210) 562-5016. E-mail: RIBOT{at}UTHSCSA.EDU.

{dagger} Present address: Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, Cantonal Hospital, 9007 St. Gallen, Switzerland.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3657-3659, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3657-3659.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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