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Antimicrobial Agents and Chemotherapy, November 2003, p. 3660-3662, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3660-3662.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Norfloxacin-Induced Electroencephalogram Alteration and Seizures in Rats Are Not Triggered by Enhanced Levels of Intracerebral Glutamate{dagger}

Marylore Chenel,1,2 Anne Limosin,1,2 Sandrine Marchand,1 Joël Paquereau,3 Olivier Mimoz,1,4 and William Couet1*

Equipe Médicaments anti-infectieux et barrière hémato-encéphalique, PBS, Faculté de Médecine & Pharmacie, 86022 Poitiers Cedex,1 Laboratoire de Pharmacocinétique, PBS, CHU La Milétrie, 86022 Poitiers Cedex,2 Equipe Sommeil: Attention et Respiration, PBS, Faculté de Médecine & Pharmacie, 86022 Poitiers Cedex,3 Département d'Anesthésie et Réanimation Chirurgicale, CHU La Milétrie, 86000 Poitiers Cedex, France4

Received 10 March 2003/ Returned for modification 9 July 2003/ Accepted 20 August 2003

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram (EEG) effect was combined with intracerebral glutamate determinations using microdialysis for rats receiving norfloxacin intravenously (150 mg/kg of body weight). The EEG effect (accompanied by tremors and seizures) was consistently observed without glutamate level modifications. Therefore, norfloxacin-inducted seizures are not triggered by intracerebral glutamate level enhancement.

* Corresponding author. Mailing address: Equipe Médicament Anti-infectieux et Barrière Hémato Encéphalique, PBS, Faculté de Médecine & Pharmacie, 40 avenue du Recteur Pineau, 86022 Poitiers Cedex, France. Phone: 33 5 49 45 43 79. Fax: 33 5 49 45 43 78. E-mail: william.couet{at}univ-poitiers.fr.

{dagger} This article is dedicated to the memory of our colleague Serge Bouquet, deceased on 14 January 2003.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3660-3662, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3660-3662.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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