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Antimicrobial Agents and Chemotherapy, November 2003, p. 3667-3671, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3667-3671.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of a New Des-Fluoro(6) Quinolone, Garenoxacin, against Clinical Anaerobic Bacteria

A. Liebetrau,1* A. C. Rodloff,1 J. Behra-Miellet,2 and L. Dubreuil2

Institute of Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany,1 Head Department of Microbiology, Faculty of Pharmacy, University of Lille, Lille, France2

Received 11 February 2003/ Returned for modification 5 June 2003/ Accepted 20 August 2003

The antimicrobial activities of garenoxacin and eight other antibiotics against 641 anaerobic isolates were evaluated with the NCCLS agar dilution method. Overall, the MICs of garenoxacin for 50 and 90% of the strains tested (in micrograms per milliliter) were as follows: Bacteroides fragilis group, 0.5 and 2; Prevotella spp., 0.25 and 2; Fusobacterium spp., 0.25 and 0.5; Porphyromonas spp., 0.125 and 0.25; Bilophila wadsworthia, 0.5 and 1; Veillonella spp., 0.25 and 0.5; Clostridium spp., 0.25 and 1; Clostridium difficile, 2 and >64; Bifidobacterium spp., 1 and 2; Eggerthella lenta, 0.25 and 1; Propionibacterium spp., 0.5 and 0.5; gram-positive cocci, 0.125 and 0.25.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstraße 24, 04103 Leipzig, Germany. Phone: 49-341-9715294. Fax: 49-341-9715209. E-mail: liea{at}medizin.uni-leipzig.de.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3667-3671, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3667-3671.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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