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 Previous Article

Antimicrobial Agents and Chemotherapy, November 2003, p. 3672-3673, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3672-3673.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan

Tsi-Shu Huang,1,2 Susan Shin-Jung Lee, Hui-Zin Tu,1 Wen-Kuei Huang,3 Yao-Shen Chen,3 Chung-Kai Huang,3 Shue-Ren Wann,3 Hsi-Hsun Lin,3 and Yung-Ching Liu1,3*

Section of Microbiology and Infectious Diseases, Kaohsiung Veterans General Hospital,1 Department of Medical Technology, Foo-Yin Institute of Technology,2 National Yang-Ming Medical College, Taipei, Taiwan3

Received 11 April 2003/ Returned for modification 6 July 2003/ Accepted 15 August 2003

A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.

* Corresponding author. Mailing address: Kaohsiung Veterans General Hospital, Section of Infectious Diseases, 386 Ta-Chung 1st Rd., Kaohsiung, Taiwan, Republic of China. Phone: 886 7-346-8098. Fax: 866 7-346-8296. E-mail: ssjlee{at}vghks.gov.tw.

Antimicrobial Agents and Chemotherapy, November 2003, p. 3672-3673, Vol. 47, No. 11
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.11.3672-3673.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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