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Antimicrobial Agents and Chemotherapy, December 2003, p. 3945-3949, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3945-3949.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Epidemiology of orf513-Bearing Class 1 Integrons in Multiresistant Clinical Isolates from Argentinean Hospitals

Sonia M. Arduino,1* Mariana Catalano,1 Betina E. Orman,1 Paul H. Roy,2,3 and Daniela Centrón1

Facultad de Medicina de la Universidad de Buenos Aires, (1121) Capital Federal, Argentina,1 Département de Biochimie, Faculté des Sciences et de Génie, Université Laval, Sainte-Foy, Québec, Canada G1K 7P4,2 Centre de Recherche en Infectiologie, Centre de Recherche du CHUL, Sainte-Foy, Québec, Canada G1V 4G23

Received 12 March 2003/ Returned for modification 23 May 2003/ Accepted 4 September 2003

The spread of orf513-bearing class 1 integrons is associated with blaCTX-M-2 in gram-negative clinical isolates in Argentina, with In35 being the most frequently found integron (74%). Among 65 isolates without blaCTX-M-2, only one harbored a novel orf513-bearing class 1 integron with the dfrA3b gene. The finding of orf513 not associated with class 1 integrons in two gram-positive strains indicates the widespread occurrence of this putative site-specific recombinase.

* Corresponding author. Mailing address: Dept. Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, P-12, (1121) Capital Federal, Argentina. Phone: 54-11-5950-9500. Fax: 54-11-4508-3705. E-mail: Sonia.Arduino{at}crchul.ulaval.ca.

Antimicrobial Agents and Chemotherapy, December 2003, p. 3945-3949, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3945-3949.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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