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Antimicrobial Agents and Chemotherapy, December 2003, p. 3970-3972, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3970-3972.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Mannosyl Glycodendritic Structure Inhibits DC-SIGN-Mediated Ebola Virus Infection in cis and in trans

Fátima Lasala,1 Eva Arce,2 Joaquín R. Otero,1 Javier Rojo,2* and Rafael Delgado1*

Laboratorio de Microbiología Molecular, Servicio de Microbiología, Hospital Universitario 12 de Octubre, Madrid,1 Grupo Carbohidratos, Instituto de Investigaciones Químicas, Consejo Superior de Investigaciones Centíficas, Seville,Spain2

Received 24 June 2003/ Returned for modification 22 July 2003/ Accepted 2 September 2003

We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.

* Corresponding author. Mailing address for Javier Rojo: Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Isla de la Cartuja, Americo Vespucio s/n, Sevilla 41092, Spain. Phone: 011-34-95-448-9568. Fax: 011-34-95-446-0565. E-mail: javier.rojo{at}iiq.csic.es.

* Mailing address for Rafael Delgado: Laboratorio de Microbiología Molecular, Servicio de Microbiología, Hospital Universitario 12 de Octubre, Ave. de Córdoba s/n, Madrid 28041, Spain. Phone: 011-34-91-390-8428. Fax: 011-34-91-565-2765. E-mail: rdelgado.hdoc{at}salud.madrid.org.

Antimicrobial Agents and Chemotherapy, December 2003, p. 3970-3972, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3970-3972.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Brindley, M. A., Hughes, L., Ruiz, A., McCray, P. B. Jr., Sanchez, A., Sanders, D. A., Maury, W. (2007). Ebola Virus Glycoprotein 1: Identification of Residues Important for Binding and Postbinding Events. J. Virol. 81: 7702-7709 [Abstract] [Full Text]  
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