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Antimicrobial Agents and Chemotherapy, December 2003, p. 3976-3978, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3976-3978.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Efficacy of Voriconazole in Treatment of Systemic Scedosporiosis in Neutropenic Mice

Javier Capilla, Carolina Serena, F. Javier Pastor, Montserrat Ortoneda, and Josep Guarro*

Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain

Received 23 April 2003/ Returned for modification 21 May 2003/ Accepted 30 August 2003

We have evaluated the efficacy of voriconazole (VRC) in a murine model of systemic infection by Scedosporium apiospermum. The survival of mice treated with VRC at 5, 20, or 40 mg/kg/day was greater than that of the control group (P <= 0.0009). VRC reduced the tissue burden in the spleen and brain (P < 0.001 in both organs) in comparison with that of the control group.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, 21 Sant Llorenç St., 43201 Reus, Spain. Phone: 977 759 359. Fax: 977 759 322. E-mail: umb{at}fmcs.urv.es.

Antimicrobial Agents and Chemotherapy, December 2003, p. 3976-3978, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3976-3978.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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