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Efficacy of Voriconazole in Treatment of Systemic Scedosporiosis in Neutropenic Mice

Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain

Received 23 April 2003/ Returned for modification 21 May 2003/ Accepted 30 August 2003

We have evaluated the efficacy of voriconazole (VRC) in a murine model of systemic infection by Scedosporium apiospermum. The survival of mice treated with VRC at 5, 20, or 40 mg/kg/day was greater than that of the control group (P 0.0009). VRC reduced the tissue burden in the spleen and brain (P < 0.001 in both organs) in comparison with that of the control group.

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