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Antimicrobial Agents and Chemotherapy, December 2003, p. 3979-3981, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3979-3981.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Genotypes of Pneumocystis jiroveci Isolates Obtained in Harare, Zimbabwe, and London, United Kingdom

Robert F. Miller,1* Austin R. Lindley,2 Helen E. Ambrose,2 Adam S. Malin,3,{dagger} and Ann E. Wakefield2,{ddagger}

Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, London WC1E 6AU,1 Molecular Infectious Diseases Group, Department of Paediatrics, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom,2 Department of Clinical Pharmacology, University of Zimbabwe Clinical School, Parirenyatwa Hospital, Harare, Zimbabwe3

Received 12 May 2003/ Returned for modification 17 June 2003/ Accepted 8 September 2003

Isolates of Pneumocystis jiroveci from sulfa-exposed and nonexposed patients from London, United Kingdom, and Harare, Zimbabwe, were genotyped. At the dihydropteroate synthase (DHPS) locus, there was evidence of selection pressure from sulfa drug exposure, and reversal of DHPS genotype ratios occurred when selection pressure was absent or was removed.

* Corresponding author. Mailing address: Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, Mortimer Market Centre, London WC1E 6AU, United Kingdom. Phone: 44 207 380 9945. Fax: 44 207 380 9669. E-mail: rmiller{at}gum.ucl.ac.uk.

{dagger} Present address: Department of Respiratory Medicine, Royal United Hospital, Bath BA1 1NG, United Kingdom.

{ddagger} Deceased.

Antimicrobial Agents and Chemotherapy, December 2003, p. 3979-3981, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3979-3981.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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