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Antimicrobial Agents and Chemotherapy, December 2003, p. 3982-3984, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3982-3984.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Efficacy of Sulforaphane in Eradicating Helicobacter pylori in Human Gastric Xenografts Implanted in Nude Mice

Xavier Haristoy,1 Karine Angioi-Duprez,2 Adrien Duprez,3 and Alain Lozniewski1*

Laboratoire de Bactériologie-Virologie, UMR CNRS 75-65,1 Laboratoire de Microchirurgie Expérimentale,2 Laboratoire d'Anatomie Pathologique EMI INSERM 0014,Faculté de Médecine, Université Henri-Poincaré, Vandæuvre-les-Nancy, France3

Received 15 November 2002/ Returned for modification 24 May 2003/ Accepted 25 August 2003

Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts, has shown in vitro activity against Helicobacter pylori. We evaluated the effect of sulforaphane in vivo against this bacterium by using human gastric xenografts in nude mice. H. pylori was completely eradicated in 8 of the 11 sulforaphane-treated grafts. This result suggests that sulforaphane might be beneficial in the treatment of H. pylori-infected individuals.

* Corresponding author. Mailing address: Laboratoire de Bactériologie, Hôpital Central, 29 Avenue du Maréchal de Lattre de Tassigny, 54035 Nancy Cedex, France. Phone: (33) 3 83 85 21 96. Fax: (33) 3 83 85 26 73. E-mail: a.lozniewski{at}chu-nancy.fr.

Antimicrobial Agents and Chemotherapy, December 2003, p. 3982-3984, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3982-3984.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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