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Antimicrobial Agents and Chemotherapy, December 2003, p. 3989-3993, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3989-3993.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Prevalence of Extended-Spectrum ß-Lactamase-Producing Enterobacter cloacae in the Asia-Pacific Region: Results from the SENTRY Antimicrobial Surveillance Program, 1998 to 2001

J. M. Bell,1* J. D. Turnidge,1 R. N. Jones,2 and the SENTRY Asia-Pacific Participants{dagger}

Microbiology and Infectious Diseases Department, Women's and Children's Hospital, Adelaide, Australia,1 The JONES Group/JMI Laboratories, North Liberty, Iowa, and The Tufts University School of Medicine, Boston, Massachusetts2

Received 9 January 2003/ Returned for modification 17 May 2003/ Accepted 30 August 2003

Enterobacter cloacae strains from hospitalized patients with a range of infections were collected by 17 laboratories in the Asia-Pacific region and South Africa. Isolates for which ceftriaxone MICs were above 1 µg/ml and/or ceftazidime MICs were above 2 µg/ml, as well as 46 strains for which ceftriaxone and/or ceftazidime MICs were at or below these values, were screened for levels of extended-spectrum ß-lactamase (ESBL) production through the use of broth microdilution for the detection of clavulanate enhancement of the activity of ceftriaxone, ceftazidime, and cefepime. Of the isolates examined, ceftriaxone and/or ceftazidime had elevated MICs for 44%, of which 36% were ESBL positive. ESBL-positive strains were commonly susceptible to piperacillin-tazobactam and more frequently resistant to several other antimicrobials studied. A cefepime MIC above 0.25 µg/ml had the highest sensitivity (100%) and specificity (74%) for predicting the presence of an ESBL.

* Corresponding author. Mailing address: Microbiology and Infectious Diseases Department, Women's and Children's Hospital, 72 King William Rd., North Adelaide, SA, 5006 Australia. Phone: 61-8-8204-6359. Fax: 61-8-8204-6051. E-mail: bellj{at}mail.wch.sa.gov.au.

{dagger} SENTRY Asia-Pacific participants are listed in Acknowledgments.

Antimicrobial Agents and Chemotherapy, December 2003, p. 3989-3993, Vol. 47, No. 12
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.12.3989-3993.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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