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Antimicrobial Agents and Chemotherapy, February 2003, p. 529-532, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.529-532.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Activity of Tigecycline (GAR-936), a Novel Glycylcycline, against Enterococci in the Mouse Peritonitis Model

Center for the Study of Emerging and Re-Emerging Pathogens,¹ Division of Infectious Diseases, Department of Internal Medicine,² Department of Microbiology and Molecular Genetics, The University of Texas Medical School, Houston, Texas³

Received 11 July 2002/ Returned for modification 17 September 2002/ Accepted 10 November 2002

A novel glycylcycline agent, tigecycline (GAR-936), was evaluated in vivo in the mouse model of peritonitis against three Enterococcus faecalis and four Enterococcus faecium isolates with different susceptibilities to vancomycin and tetracyclines, all of which were inhibited by 0.125 µg of tigecycline/ml. Using a single subcutaneous dose, tigecycline displayed a protective effect (50% protective dose, 5.7 mg/kg of body weight) against all strains tested, including two with Tn925 (from the Tn916 family), which contains the Tet(M) tetracycline resistance determinant, as well as VanA and VanB strains. As expected, tetracycline and minocycline were ineffective against the isolates carrying Tn925.

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