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Antimicrobial Agents and Chemotherapy, February 2003, p. 727-734, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.727-734.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Epidemiology of the SRL Pathogenicity Island

Sally A. Turner, Shelley N. Luck, Harry Sakellaris, Kumar Rajakumar,{dagger} and Ben Adler*

Bacterial Pathogenesis Research Group, Department of Microbiology, Monash University, Victoria 3800, Australia

Received 15 July 2002/ Returned for modification 17 October 2002/ Accepted 19 November 2002

The Shigella resistance locus (SRL), which is carried on the SRL pathogenicity island (PAI) in Shigella flexneri 2a YSH6000, mediates resistance to the antibiotics streptomycin, ampicillin, chloramphenicol, and tetracycline. In the present study, we investigated the distribution and structural variation of the SRL and the SRL PAI in 71 Shigella isolates and 28 other enteric pathogens by PCR and Southern analysis. The SRL and SRL-related loci, although absent from the other enteric pathogens evaluated in this study, were found to be present in a number of Shigella isolates. SRL PAI markers were also present in the majority of strains carrying the SRL and SRL-related loci. PCR linkage studies with six of these strains demonstrated that the SRL is carried on elements similar in structure and organization to the YSH6000 SRL PAI, consistent with the hypothesis that the SRL PAI may be involved in the spread of multiple-antibiotic resistance in these strains.

* Corresponding author. Mailing address: Department of Microbiology, Monash University, P.O. Box 53, Victoria 3800, Australia. Phone: (61 3 99054815). Fax: (61 3 99054811). E-mail: Ben.Adler {at}med.monash.edu.au.

{dagger} Present address: Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN, United Kingdom.

Antimicrobial Agents and Chemotherapy, February 2003, p. 727-734, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.727-734.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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