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Antimicrobial Agents and Chemotherapy, February 2003, p. 790-793, Vol. 47, No. 2
0066-4804/03/$08.00+0     DOI: 10.1128/AAC.47.2.790-793.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Clinical Isolates of Enterobacteriaceae Producing Extended-Spectrum ß-Lactamases: Prevalence of CTX-M-3 at a Hospital in China

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China,¹ Department of Medicine, University of Illinois, Chicago, Illinois 60612²

Received 14 May 2002/ Returned for modification 17 August 2002/ Accepted 10 November 2002

The prevalence of extended-spectrum ß-lactamase-producing strains was demonstrated in 5 of 44 (11.4%) Escherichia coli, 17 of 43 (39.5%) Klebsiella pneumoniae, 3 of 50 (6.0%) Enterobacter cloacae, and 2 of 25 (8.0%) Citrobacter freundii strains at a teaching hospital in China. Nineteen of these 27 strains expressed CTX-M-3 ß-lactamase (pI 8.6). A subset of the clinical isolates expressing the CTX-M-3 enzyme, tested by pulsed-field gel electrophoresis, revealed multiple clones. Five isolates expressed a novel enzyme, SHV-43 (pI 8.0), which had two substitutions (Leu113Phe and Thr149Ser) compared with SHV-1.

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